Texas Chiropractic College occupies a 16-acre tract, which is home to an array of buildings containing classrooms, laboratories, clinics, library facilities, and faculty and administrative offices.
- The Standard Process Student Center, formerly the James M. Russell Education Center, built in 1978 and remodeled in 2014-15. The Center contains four classrooms, a student lounge, a cafeteria, a multipurpose auditorium and two physical workout spaces for the college community.
- The Dr. Nobunori Iwama Anatomical Building, formerly the Turley Anatomical Building, was erected in 1979 and renovated in 2014. The building is the home of the gross anatomy laboratory. The renovations included the installation of state-of-the-art equipment, ventilation, flooring, HVAC and high intensity lighting.
- In 1982, the Learning Resource Center was opened. With more than 35,000-square feet of space, this building houses the Mae Hilty Memorial Library, a bookstore, four classrooms, a laboratory, and various student government offices.
- The Guy and Esther Ligon Laboratory Building (1997) is home to two adjusting labs, the rehabilitation and active care lab, and a computer teaching lab used with digital imaging and other courses.
- The William M. Harris Administrative Building (1998). This two-story structure houses the offices of the President, Institutional Advancement, Business, Financial Aid, Admission, Student Services, Registrar, Postgraduate Studies and Alumni Relations.
- The Moody Health Center (MHC), a multidisciplinary facility, opened in June 2000 for continuation of intern training under licensed attending chiropractic clinicians. The MHC was designed to provide integrative health care services and provides patient care for the surrounding community.
- In April 2006, the College opened the Dr. Yasunori Iwama Education Center. This facility contains 45 faculty offices, a 4,000-square foot state-of-the-art assessment center, a chemistry laboratory, and a 750-seat auditorium that includes classroom seating for up to 100 students.
- Hampton Tax Group Recreation Center opened March 2022. Featured amenities include a workout facility, showers, game tables, lounge areas, a movie room, and an outdoor multi-sport court.